Newly Identified Plant Compounds Disrupt the Unique-to-Insects Juvenile Hormone Complex Receptor; Compounds Effectively and Safely Target Yellow-Fever Mosquitoes, Promise Similar Success Against Wide Range of Insect Pests & Disease Carriers

Each year, millions of deaths result from diseases transmitted by insects. Insects are also responsible for major economic losses, worth billions of dollars annually, by damaging crops and stored agricultural products. Many currently available insecticides present environmental and health risks. Further, insects develop resistance to existing insecticides, complicating pest-control strategies. The need to develop novel effective insecticides is therefore urgent. Enter "insect-specific growth regulators," which, as their name suggests, are compounds that regulate the growth of insects. They represent attractive pest-control agents because they pose no health risk to humans and are also environmentally safe. One hormone in insects, called juvenile hormone, is a particularly attractive target for insect growth regulators because this hormone exists only in insects. Juvenile hormone plays key roles in insect development, reproduction, and other physiological functions. An international team of scientists, including an entomologist at the University of California, Riverside (UCR), has investigated in detail how juvenile hormone acts and has devised a method to prevent its working. The researchers, led in the United States by Dr. Alexander Raikhel, a Distinguished Professor of Entomology at UCR, discovered potent compounds in plants that counteract the action of juvenile hormone. These compounds, called juvenile hormone antagonists (JHANs), make up plants' innate resistance mechanism against insect herbivores. In collaboration with Korean scientists, Dr. Raikhel's lab screened 1,651 plant species and chose active JHANs from these plants. They then identified five JHANs from two plants that are effective in causing mortality of yellow fever mosquito larvae, specifically by retarding the development of ovaries.
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