Visualizing gene expression in single cells is one of the newest and fastest-moving areas in cell biology. The field has exploded from the single-cell emulsion droplet barcoding technique published in 2015 to new techniques to profile the heterogeneity of tumors, whole organs, and even whole organisms. “Malignant features have natural length scales that span an enormous range, from nanometers to meters. It’s important to preserve the spatial information in cancer because so many processes are incredibly difficult to recapitulate in vitro,” said H. Courtney Hodges, PhD, Baylor College of Medicine. “If we want to understand the processes that contribute to malignancy and the plasticity of tumor cell biology, we need to be able to explore the genomic dependencies of these processes in a way that preserves their spatial contexts.” Dr. Hodges was chair of the Educational Session on Saturday, April 9, that provided an update on the latest techniques that enable dissection and characterization of tumors with unprecedented precision. The American Association for Cancer Research (AACR) Annual Meeting, was held April 8-13 in New Orleans. The Education Session, Single Cell Biology in Scale and Spatial Genomics, and other meeting sessions can be viewed on the virtual platform by registered meeting participants through July 13, 2022. Registration can be done here. Over 19,000 scientists and physicians registered for this premier cancer conference, with ~80% (~15,200) attending in person and ~20% (~3,800) attending virtually. The AACR has over 50,000 members worldwide.