New Target Identified in Mechanism for Pulmonary Hypertension

Dushani Ranasinghe, PhD, left, and Margaret Schwarz, MD, at Ranasinghe's graduation ceremony from the University of Notre Dame(Credit: Courtesy of Margaret Schwarz)
Indiana University School of Medicine researchers at the school’s South Bend regional campus, in collaboration with colleagues at the University of Notre Dame, have identified a new therapeutic target for pulmonary hypertension, a type of high blood pressure that affects the blood vessels in the lungs. Their findings were published on September 12, 2023 in Circulation Research. The open-access article is titled “Altered Smooth Muscle Cell Histone Acetylome by the SPHK2/S1P Axis Promotes Pulmonary Hypertension.”
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