New Study Shows Fibromyalgia Likely the Result of Autoimmune Problems; Patient Antibodies Cause Fibromyalgia Symptoms in Mice; Therapies Directed Against Autoimmunity May Offer Significant Treatment Hope; “Implications Are Profound”

New research from the Institute of Psychiatry, Psychology, & Neuroscience (IoPPN) at King’s College London, in collaboration with the University of Liverpool and the Karolinska Institute, has shown that many of the symptoms in fibromyalgia syndrome (FMS) are caused by antibodies that increase the activity of pain-sensing nerves throughout the body. The results show that fibromyalgia is a disease of the immune system, rather than the currently held view that it originates in the brain. The study, published online on July 1, 2021 in the Journal of Clinical Investigation, demonstrates that the increased pain sensitivity, muscle weakness, reduced movement, and reduced number of small nerve-fibers in the skin that are typical of FMS, are all a consequence of patient antibodies. The open-access article is titled “'Passive Transfer of Fibromyalgia Symptoms from Patients to Mice.”

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