The first step in the development of the allergic conjunctivitis is the penetration of the allergen through the epithelial layer. However, the mechanism of allergen transport is still unknown. Now, researchers from Japan have discovered that goblet cell-associated antigen passage formed by specialized epithelial cells called “goblet cells” plays an important role in the development of conjunctival disease, and can be a novel therapeutic target for treating allergic conjunctivitis. When it comes to eye allergies, the transition from allergen contact to bothersome symptoms has always been quick, appearing within a span of a few minutes. The initial stage of allergic conjunctivitis involves the penetration of allergen through the epithelial cell layer (cells covering the outer surface of the body). However, the exact mechanism underlying the rapid allergen transfer has remained a mystery so far.