New Study Focuses on Placenta for Clues to Development of Gestational Diabetes

Marie-France Hivert, MD

A new study led by the Harvard Pilgrim Health Care Institute has identified that a deficit in the placental expression of the gene insulin-like growth factor 1 (IGFBP1) and low IGFBP1 circulating levels are associated with insulin resistance during pregnancy, highlighting a potential risk factor for the development of gestational diabetes. The study, “Placental IGFBP1 Levels During Early Pregnancy and the Risk of Insulin Resistance and Gestational Diabetes,” appears in the April 16, 2024 edition of Nature Medicine. The open-access article is titled “Placental IGFBP1 Levels During Early Pregnancy and the Risk of Insulin Resistance and Gestational Diabetes.”

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