New Study Deepens Understanding of Regulation of Circadian Rhythms in Mammalian Central Clock

Circadian rhythms are inherent cycles of approximately 24 hours that regulate various biological processes, such as sleep and wakefulness. A research group at Nagoya University in Japan has recently revealed that neural networks play an important role in the regulation of circadian rhythms through the mediation of an intracellular molecule called cyclic adenosine monophosphate (cAMP). This finding may pave the way for new strategies to treat sleep disorders and other chronic  health conditions affected by disruption of the circadian rhythm. The study was published on January 4, 2023 in Science Advances. The open-access article is titled “Network-Driven Intracellular cAMP Coordinates Circadian Rhythm in the Suprachiasmatic Nucleus.”