New Ribosome-Targeted Synthetic Antibiotic (Cresomycin) Highly Effective Against Drug-Resistant Bacteria

Molecular model of bacterial ribosome
A new synthetic antibiotic created by Harvard researchers, and colleagues from the University of Illinois-Chicago (UIC), overcomes antimicrobial resistance mechanisms that have rendered many modern drugs ineffective and are driving a global public health crisis. A team led by Andrew Myers, PhD, the Amory Houghton Professor of Chemistry and Chemical Biology at Harvard, reported on February 15, 2024 in Science that their synthetic compound, cresomycin, kills many strains of drug-resistant bacteria, including Staphylococcus aureus and Pseudomonas aeruginosa. The Science article is titled “An Antibiotic Preorganized for Ribosomal Binding Overcomes Antimicrobial Resistance.”
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