New “Protein Blueprinting” Technique Will Likely Supplant Existing Approaches and Vastly Increase Efficiency of Drug Discovery & Early Stages of Drug Development

Biochemists from Trinity College Dublin, together with colleagues, have devised a new technique that will make the difficult, but critical, job of blueprinting certain proteins considerably faster, cheaper, and easier. The breakthrough will likely make a big splash in the field of drug discovery and development, where precise protein structure blueprints can help researchers understand how individual proteins work. Critically, these blueprints can show weaknesses that allow drug developers to draw up specific battle plans in the fight against diseases and infections. Professor of Membrane Structural and Functional Biology at Trinity, Dr. Martin Caffrey, is the senior author of the research, which has just been published in the international peer-reviewed journal Acta Crystallographica D. Dr. Caffrey said: "This is a truly exciting development. We have demonstrated the method on a variety of cell membrane proteins, some of which act as transporters. It will work with existing equipment at a host of facilities worldwide, and it is very simple to implement." Over 50% of drugs on the market target cell membrane proteins, which are vital for the everyday functioning of complex cellular processes. These proteins act as transporters to ensure that specific molecules enter and leave our cells, as signal interpreters important in decoding messages and initiating responses, and as agents that speed up appropriate responses. The major challenge facing researchers is the production of crystals of large membrane proteins, which are used to determine the precise 3-D structural blueprints. That challenge has now been lessened thanks to the Trinity biochemists' advance - the in meso in situ serial crystallography (IMISX) method.
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