New Insights into Lung Adenocarcinoma’s Early Development Revealed in Recent Study 

by Manisha Kashyap, PhD

Markers of alveolar intermediate cells, termed KRT8+ alveolar cells (KACs), identified by Kadara and colleagues within a lung tumor. KRT8 in shown in red, DAPI in blue and LAMP3, a marker of AT2 cells, in teal. (Credit: Kadara laboratory.)

Lung adenocarcinoma (LUAD), the most common form of lung cancer, presents a formidable challenge for clinicians worldwide. With its tendency to develop at the periphery of the lung, often escaping early detection, and a notable propensity for recurrence, even after initial treatment, LUAD remains a significant cause of morbidity and mortality. However, a ground-breaking study published February 28, 2024 in Nature offers fresh insights into the initiation and early development of LUAD, potentially paving the way for more effective early treatment strategies. The open-access article is titled “An Atlas of Epithelial Cell States and Plasticity in Lung Adenocarcinoma.” The Nature article is accompanied by a Nature Portfolio piece outlining the study.

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