New DNA Repair Kit Using Baculovirus Delivery System Successfully Corrects Hereditary Kidney Disease Defect in Patient-Derived Cells

Genetic mutations which cause a debilitating hereditary kidney disease affecting children and young adults have been fixed in patient-derived kidney cells using a potentially game-changing DNA repair-kit. The advance, developed by University of Bristol (UK) scientists, was published on July 22, 2022 in Nucleic Acids Research. The open-access article is titled “Highly Efficient CRISPR-Mediated Large DNA Docking and Multiplexed Prime Editing Using a Single Baculovirus.” In this new study, the international team describe how they created a DNA repair vehicle to genetically fix faulty podocin, a common genetic cause of inheritable steroid-resistant nephrotic syndrome (SRNS).