New Biomarkers Found to Predict Kidney Failure in Type 1 Diabetes Patients

Results from a study led by City of Hope researchers and published in Science Translational Medicine could help with early detection and prevention of kidney disease in a vulnerable population.

Rama Natarajan, PhD
In a paper published May 22, 2024 in Science Translational Medicine, researchers from City of Hope®, one of the largest cancer research and treatment organizations in the United States and a leading research center for diabetes and other life-threatening illnesses, report that they have discovered advances in predicting kidney failure in type 1 diabetes (T1D) patients. The article is titled “Integrated Analysis of Blood DNA Methylation, Genetic Variants, Circulating Proteins, MicroRNAs, and Kidney Failure in Type 1 Diabetes.” By performing the first epigenome-wide association analysis in patients with diabetic kidney disease, a team led by Rama Natarajan, Ph.D., Deputy Director of the Arthur Riggs Diabetes & Metabolism Research Institute at City of Hope, identified novel associations between DNA methylation activity — a biological process that can change the activity of a DNA segment — and a subsequent risk of developing kidney failure in a number of years.
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