Neutrophils Halt Migration When They Sense Reactive Oygen Species

Neutrophils are the superheroes of the body's immune system. Normally mild-mannered, they travel through the bloodstream until they reach an emergency situation, such as a cut or infection, where they switch into battle-mode to engulf and destroy foreign invaders. How do these microscopic avengers transition from silent, patrolling responders to merciless killing machines? Researchers from the University of Illinois at Chicago (UIC), the National Institutes of Health, and Fudan University in Shanghai have found that the key is a receptor molecule in the cell that senses reactive oxygen species. The finding was published online on August 25, 2016 in Developmental Cell. The article is titled “Oxidant Sensing by TRPM2 Inhibits Neutrophil Migration and Mitigates Inflammation.” Reactive oxygen species, or ROS, are produced by the body as a byproduct of metabolism. They are harmful to cells at high levels, because they can bond to and damage molecules that the cell relies on, like DNA. A receptor called TRPM2 acts as an ROS sensor or gauge inside the neutrophil. When ROS levels are low, the neutrophil is on the move, looking for infections to fight. As the neutrophil nears a wound site and begins to encounter foreign particles or bacteria, it engulfs them and generates a killing burst of ROS to destroy the captured enemy. TRPM2 senses these consistent, high levels of ROS inside the cell and puts the neutrophil in park, so the cell stays in place to continue killing invading microbes. "The neutrophil senses a dramatic increase in reactive oxygen species as it gets closer to the wound site, and this triggers the shutdown of the migration of the cell," said Jingsong Xu, Ph.D., Assistant Professor of Pharmacology in the UIC College of Medicine and corresponding author on the paper.
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