“Multiple Viruses Detected in Human DNA Are Associated with Alzheimer Disease Risk” ASHG Poster Presentation

Marlene Tejeda

ASHG Abstract Presented by Marlene Tejeda, Boston University School of Medicine, Boston, Massachusetts.

In their abstract, Tejeda and colleagues wrote the following:

Background: Multiple infectious agents have been identified as risk factors for Alzheimer’s disease (AD). Viruses can cause inflammatory damage and potentially increase the formation of the AD hallmark proteins amyloid-beta protein and hyperphosphorylated tau. We and others previously reported association between AD and the quantity of whole genome and whole exome sequence reads mapping to herpes simplex type 1 (HSV-1), human herpes virus 6B (HHV-6B), and human papilloma virus 71 (HPV-71). Here, we conducted GWAS using these viruses to identify genetic associations that (1) affect viral load and (2) modify the effect of viral load on AD risk.

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