ASHG Abstract Presented by Marlene Tejeda, Boston University School of Medicine, Boston, Massachusetts.
In their abstract, Tejeda and colleagues wrote the following:
Background: Multiple infectious agents have been identified as risk factors for Alzheimer’s disease (AD). Viruses can cause inflammatory damage and potentially increase the formation of the AD hallmark proteins amyloid-beta protein and hyperphosphorylated tau. We and others previously reported association between AD and the quantity of whole genome and whole exome sequence reads mapping to herpes simplex type 1 (HSV-1), human herpes virus 6B (HHV-6B), and human papilloma virus 71 (HPV-71). Here, we conducted GWAS using these viruses to identify genetic associations that (1) affect viral load and (2) modify the effect of viral load on AD risk.