mRNA Delivered by Extracellular Vesicles (EVs) Induces Immunotherapy Response in Glioblastoma; Preclinical Study Suggests Method Could Be Adapted to Other Hard-to-Treat Tumor Types

A team of researchers at The University of Texas MD Anderson Cancer Center has developed a new method for using extracellular vesicles (EVs) to enhance responses to immunotherapy in glioblastoma, potentially opening the door for wider use of engineered messenger RNA (mRNA) for cancer therapy. The study was published on October 19, 2023 in Nature Communications. The open-access article is titled “Adaptive Design of mRNA-Loaded Extracellular Vesicles for Targeted Immunotherapy of Cancer.”