Mineral Coatings Could Enable Shelf-Stable mRNA Therapies

A protective mineral coating identified by University of Wisconsin–Madison biomedical engineering researchers could allow powerful messenger RNA therapeutics like COVID-19 vaccines to be stored at room temperature, making them more accessible to lower-resourced communities across the world. In a new paper in the journal Acta Biomaterialia, Professor William Murphy and collaborators in his lab detail how using an optimized mineral coating composition can maintain mRNA activity for up to six months at room temperature. With that kind of preservation, mRNA therapeutics — vaccines against infectious diseases, but also emerging treatments for cancer and tissue regeneration — could be stored on the shelf at local clinics. The open-access article was published December 6, 2023, and is titled “Optimized Biomimetic Minerals Maintain Activity of mRNA Complexes After Long Term Storage.”

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