MicroRNA Biomarker Panel for Possible Early Detection of Preeclampsia and Prediction of Severity

Louise Laurent, MD, PhD

This posting is based on article published in Inside Precision Medicine.

Research led by the University of California San Diego (UCSD) shows that a panel of micro (mi)RNA biomarkers can predict preeclampsia and also indicate how severe the condition is likely to be. The researchers initially identified 110 extracellular miRNAs, which can move between cells, that were linked to preeclampsia before narrowing the markers down to a panel of three pairs of linked miRNAs with the help of machine learning. The panel of miRNA biomarkers was able to differentiate between milder and more severe cases of preeclampsia and performed even better when combined with the preexisting biomarkers placental growth factor (PlGF) and soluble FMS-like tyrosine kinase 1 (sFlt1) ratio.

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