MicroRNA-146a in Epithelial-Cell-Derived Exosomes Can Induce Production of IL-10 in Monocytes and Inhibit Skewed Th2 Polarization in Nasal Mucosa; Results Suggest Possible Treatment for Allergic Disorders Such As Allergic Rhinitis

Researchers from the Shanghai Jiaotong University School of Medicine, the Shenzhen University School of Medicine, and the Guangzhou Medical University, all in China, have shown that microRNA-146a (miRNA-146a) from epithelial-cell-derived exosomes can induce the expression of interleukin-10 (IL-10) in monocytes. The IL-10-producing monocytes are then capable of suppressing effector T cell (Teff) activities and inhibiting the skewed T helper 2 (Th2) polarization in the nasal mucosa in a mouse model of allergic retinitis. The researchers noted that, while it is well known skewed Th2 polarization plays a critical role in the pathogenesis of allergic diseases, such a pathological condition has proven refractory to correction. In their new publication, however, the Chinese scientists conclude that their present data “indicate that miR-146a can induce IL-10-producing monocytes to suppress the skewed Th2 polarization, suggesting that miR-146a has potential in the treatment of allergic disorders, such as allergic rhinitis.” This work was published online on November 3, 2015 in an open-access article in Scientific Reports. The article is titled “Epithelial Cell-Derived Micro RNA-146a Generates Interleukin-10-Producing Monocytes to Inhibit Nasal Allergy.” In further detail, the authors write that their results suggest that human nasal epithelial cells produce miR-146a, which can be up-regulated by lipopolysaccharide (LPS) and suppressed by Th2 cytokines. The miR-146a can be released from nasal epithelial cells to the microenvironment, carried in exosomes. [Scientific Reports article]
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