MicroRNA-1 Alleviates Protein Accumulation by Controlling Autophagy; Finding May Be Key to New Therapeutic Approaches in Huntington’s Disease and Parkinson’s Disease

Research led by a Monash University (Australia) scientist has identified a highly conserved mechanism in worms and humans that controls the removal of toxic protein aggregates – hallmarks of neurodegenerative diseases. Insights from their study may provide a novel therapeutic approach for diseases such as Huntington's and Parkinson's. Associate Professor Roger Pocock, from the Monash Biomedicine Discovery Institute (BDI), and colleagues from the University of Cambridge led by Professor David Rubinsztein, found that microRNAs are important in controlling protein aggregates, proteins that have amassed due to a malfunction in the process of ‘folding’ that determines their shape. The scientists’ findings were published online on December 9, 2019 in eLIFE. The open-access article is titled “Interferon-β-Induced miR-1 Alleviates Toxic Protein Accumulation by Controlling Autophagy.” MicroRNAs, short strands of genetic material, are tiny but powerful molecules that regulate many different genes simultaneously. The scientists sought to identify particular microRNAs that are important for regulating protein aggregates and homed in on miR-1, which is found in low levels in patients with neurodegenerative diseases such as Parkinson’s disease. “The sequence of miR-1 is 100 per cent conserved; it’s the same sequence in the Caenorhabditis elegans worm as in humans even though they are separated by 600 million years of evolution,” Associate Professor Pocock said. “We deleted miR-1 in the worm and looked at the effect in a preclinical model of Huntington’s and found that when you don’t have this microRNA there’s more aggregation,” he said. “This suggested miR-1 was important to remove Huntington’s aggregates.”
Login Or Register To Read Full Story