Microglial Methylation “Landscape” in Human Brain; Profiles Differ Across Age, Disease State, Brain Region, and Individual; Early Data Point to Pathology of Microglia, Key Immune Cells of Brain, in Biology of Depression

In the central nervous system, microglial cells play critical roles in development, aging, brain homeostasis, and pathology. Recent studies have shown variation in the gene-expression profile and phenotype of microglia across brain regions and between different age and disease states. But the molecular mechanisms that contribute to these transcriptomic changes in the human brain are not well understood. Now, a new study targets the methylation profile of microglia from human brain. The study was published online on October 30, 2021 in Biological Psychiatry, published by Elsevier. The open-access article is titled “Contribution of Age, Brain Region, Mood Disorder Pathology, and Interindividual Factors on Methylome of Human Microglia.”

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