In many people with autism and other neurodevelopmental disorders, different parts of the brain don't talk to each other very well. Scientists have now identified, for the first time, a way in which this decreased functional connectivity can come about. In a study published online on February 2, 2014 in Nature Neuroscience, scientists at the European Molecular Biology Laboratory (EMBL) in Monterotondo, Italy, and collaborators at the Istituto Italiano di Tecnologia (IIT), in Rovereto, and La Sapienza University in Rome, demonstrate that it can be caused by cells called microglia failing to trim connections between neurons. "We show that a deficit in microglia during development can have widespread and long-lasting effects on brain wiring and behaviour," says Dr. Cornelius Gross, who led the study. "It leads to weak brain connectivity, decreased social behavior, and increased repetitive behavior, all hallmarks of autism." The findings indicate that, by trimming surplus connections in the developing brain, microglia allow the remaining links to grow stronger, like high-speed fibre-optic cables carrying strong signals between brain regions. But if these cells fail to do their job at that crucial stage of development, those brain regions are left with a weaker communication network, which in turn has lifelong effects on behaviour. Dr. Yang Zhan, a postdoctoral fellow in Gross' lab at EMBL, analysed the strength of connections between different areas of the brain in mice that were genetically engineered to have fewer microglia during development. Working with Dr. Alessandro Gozzi's lab at IIT and Dr.
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