Life Span Increases in Mice When Specific Brain Cells Are Activated

Brain cells communicate with fat tissue to produce cellular fuel, counteract effects of aging; extracellular vesicles (EVs) involved.

In recent years, research has begun to reveal that the lines of communication between the body’s organs are key regulators of aging. When these lines are open, the body’s organs and systems work well together. But with age, communication lines deteriorate, and organs don’t get the molecular and electrical messages they need to function properly. A new study from the Washington University School of Medicine in St. Louis identifies, in mice, a critical communication pathway connecting the brain and the body’s fat tissue in a feedback loop that appears central to energy production throughout the body. The research suggests that the gradual deterioration of this feedback loop contributes to the increasing health problems that are typical of natural aging. The study — published January 8, 2024 in Cell Metabolism — has implications for developing future interventions that could maintain the feedback loop longer and slow the effects of advancing age. The open-access article is titled “DMHPpp1r17 Neurons Regulate Aging and Lifespan in Mice Through Hypothalamic-Adipose Inter-Tissue Communication.”

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