Large Study Links Gut Microbiome Changes to Increased Risk of Type 2 Diabetes

Brigham, Broad, and Harvard Chan School researchers found that specific species and strains of bacteria were linked to changes in the functioning of the gut microbiome and a person's risk of type 2 diabetes

The largest and most ethnically and geographically comprehensive investigation to date of the gut microbiome of people with type 2 diabetes (T2D), prediabetes, and healthy glucose status has found that specific viruses and genetic variants within bacteria correspond with changes in gut microbiome function and T2D risk. Results of the study—which represents a collaboration across Brigham and Women’s Hospital (a founding member of the Mass General Brigham healthcare system), the Broad Institute of MIT and Harvard, and the Harvard T.H. Chan School of Public Health—were published June 25, 2024 in Nature Medicine. The article is titled “Strain-Specific Gut Microbial Signatures in Type 2 Diabetes Identified in a Cross-Cohort Analysis of 8,117 Metagenomes.”
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