Large-Scale Meta Analysis of Brain Epigenetics Identifies 84 Genes Newly Associated with Dementia

The largest study of its kind has unveiled new insights into how genes are regulated in dementia, including the discovery of 84 genes newly associated with the disease. Led by scientists at the University of Exeter, the international collaboration combined and analyzed data from more than 1,400 people across six different studies, in a meta-analysis published online on June 10, 2021 in Nature Communications. The open-access article is titled “A Meta-Analysis of Epigenome-Wide Association Studies in Alzheimer’s Disease Highlights Novel Differentially Methylated Loci Across Cortex.”