Lab-Made Peptidomimetic Oligomers (Peptoids) Targeting Membrane Phosphatidylserine Exhibit Broad Antiviral Activity Against Enveloped Viruses

Illustration of Zika virus, an enveloped virus.
Just as bacteria can develop antibiotic resistance, viruses can also evade drug treatments. Developing therapies against these microbes is difficult because viruses often mutate or hide themselves within cells. But by mimicking the way the immune system naturally deals with invaders, researchers reporting in ACS Infectious Diseases have developed a “peptoid” antiviral therapy that effectively inactivates three enveloped viruses in lab tests. The approach disrupts the microbes by targeting certain lipids in their membranes. The open-access article was published on August 2, 2023 and is titled “Peptidomimetic Oligomers Targeting Membrane Phosphatidylserine Exhibit Broad Antiviral Activity.”
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