Japanese Team Explores Role of STING (Stimulator of Interferon Genes) in Body’s Innate Immune System

A type I interferon

When pathogens attack the body, the innate immune system goes to work protecting against the invading disease. The innate immune system is the first line of defense. It detects precisely what the virus or bacteria is and then activates the proteins that fight the pathogens. Wanting to better understand how the body’s innate immune system works, a team of scientists undertook a study of STING, a protein that plays a vital role in innate immunity. The team provides quantitative results, showing how STING, an acronym for stimulator of interferon genes, works in innate immune signaling. Their work was published in Nature Communications on January 11, 2024. The open-access article is titled “Single-Molecule Localization Microscopy Reveals STING Clustering at the Trans-Golgi Network Through Palmitoylation-Dependent Accumulation of Cholesterol.”

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