International Research Team Unveils Impact of East Asian Gene Variant on Type 2 Diabetes (T2D) Risk

It was earlier discovered that a variation in the PAX4 gene specifically predisposes East Asians to a higher risk of developing Type 2 Diabetes (T2D), increasing lifetime risk by up to 1.8 times. A new study, published in the journal Nature Communications, reveals for the first time, how an East Asian-specific PAX4 gene variant, R192H, impact the development and function of beta cells in the pancreas. These beta cells play a vital role in producing insulin, the hormone that regulates blood sugar levels and helps prevent serious complications in diabetic patients. The insights gained from this study pave the way for potential therapeutic interventions and personalized approaches in diabetes prevention and management, marking a significant step in the ongoing fight against diabetes. The open-access article is titled “PAX4 Loss of Function Increases Diabetes Risk by Altering Human Pancreatic Endocrine Cell Development.”
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