Intermittent Fasting Improves Alzheimer’s Pathology in Mouse Model; Mice on Time-Restricted Feeding Schedule Had Better Memory and Less Accumulation of Amyloid Proteins in the Brain Compared to Controls

One of the hallmarks of Alzheimer’s disease is disruption to the body’s circadian rhythm, the internal biological clock that regulates many of our physiological processes. Nearly 80% of people with Alzheimer’s experience these issues, including difficulty sleeping and worsening cognitive function at night. However, there are no existing treatments for Alzheimer’s that target this aspect of the disease. A new study from researchers at the University of California San Diego School of Medicine has shown in mice that it is possible to correct the circadian disruptions seen in Alzheimer’s disease with time-restricted feeding, a type of intermittent fasting focused on limiting the daily eating window without limiting the amount of food consumed. In the study, published August 21, 2023 in Cell Metabolism, mice that were fed on a time-restricted schedule showed improvements in memory and reduced accumulation of amyloid proteins in the brain. The authors say the findings will likely result in a human clinical trial. The open-access article is titled “Circadian Modulation by Time-Restricted Feeding Rescues Brain Pathology and Improves Memory in Mouse Models of Alzheimer’s Disease.”

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