Insight on How Selfish Genes Succeed

Stowers Institure for Medical Research

New findings from the Stowers Institute for Medical Research in Kansas City have yielded critical insights about how a dangerous selfish gene—considered to be a parasitic portion of DNA—functions and survives. Understanding this dynamic is a valuable resource for the broader community studying meiotic drive systems. The new study, published in PLoS Genetics on Dec. 7, 2022, reveals how a selfish gene in yeast uses a poison-antidote strategy that enables its function and likely has facilitated its long-term evolutionary success. This strategy is an important addition for scientists studying similar systems including teams that are designing synthetic drive systems for pathogenic pest control. Collective and collaborative advancement on understanding drive may one day lead to the eradication of pest populations that harm crops or even humans in the case of vector-borne diseases. The open-access PLoS Genetics article is titled “S. pombe wtf Drivers Use Dual Transcriptional Regulation and Selective Protein Exclusion from Spores to Cause Meiotic Drive.”

Login Or Register To Read Full Story