Immune Evasion Tactics of Liver Cancer Cells Revealed

A cancer gene drives immune escape by stopping tumor and immune cells from communicating using exosomes

Representation of exosome and its cargo

A faulty cancer gene helps tumors evade immunity by stopping tumor cells from releasing message-containing exosomes. These findings, published March 19, 2024 as a Reviewed Preprint in eLife, provide what the editors say is fundamental insight into the underlying biology of hepatocellular carcinoma (HCC), and compelling data supporting the role of beta-catenin in immune evasion. They suggest this work will be of special interest to researchers investigating the basic biology of liver function, as well as those investigating novel pathways for therapeutic targeting of liver cancer. The open-access eLife article is titled “Emerging Role of Oncogenic ß-catenin in Exosome Biogenesis As a Driver of Immune Escape in Hepatocellular Carcinoma.”

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