Immunotherapy is an effective form of therapy for different types of cancer. However, for pancreatic cancer, its effect is limited and differs between men and women. Researchers at Karolinska Institutet have now found a possible explanation for this sex difference. The study, which was published om March 15, 2023 in Cancer Research, reveals the presence of an immune cell in women with pancreatic cancer that obstructs the body’s immune response. The results can pave the way for a more sex-specific treatment. The article is titled “FPR2 Shapes an Immune-Excluded Pancreatic Tumor Microenvironment and Drives T-Cell Exhaustion in a Sex-Dependent Manner.”
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