IL-17 Protein Plays Key Role in Skin Aging

A team of scientists from the Institute for Research in Biomedicine (IRB Barcelona) in collaboration with the National Center for Genomic Analysis (CNAG) has discovered that IL-17 protein plays a central role in skin aging. The study, which was led by Dr. Guiomar Solanas and Dr. Salvador Aznar Benitah, both at IRB Barcelona, and Dr. Holger Heyn, at CNAG, highlights an IL-17-mediated aging process to an inflammatory state. Skin aging is characterized by a series of structural and functional changes that gradually contribute to the deterioration and fragility associated with age. Aged skin has a reduced capacity to regenerate, poor healing ability, and diminished barrier function. Published on June 8, 2023 in the journal Nature Aging, this work describes the changes undergone by different types of cells with aging and identifies how some immune cells in the skin express high levels of IL-17. The open-access article is titled “Targeting Lymphoid-Derived IL-17 Signaling to Delay Skin Aging.”
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