The cholera-causing bacterium, Vibrio cholerae, is commonly found in aquatic environments, such as oceans, ponds, and rivers. There, the bacterium has evolved formidable skills to ensure its survival, growth, and occasional transmission to humans, especially in endemic areas of the globe. One of the ways the pathogen defends itself against predatory aquatic amoebas involves "hitchhiking" them and hiding inside the amoeba. Once there, the bacterium resists digestion and establishes a replication niche within the host's osmoregulatory organelle. This organelle is essential for the amoeba to balance its internal water pressure with the pressure exerted by the environment. In a new study, the group of Dr. Melanie Blokesch at EPFL (Ecole Polytechnique Fédérale de Lausanne), in collaboration with the BioEM facility headed by Dr. Graham Knott, has deciphered the molecular mechanisms that V. cholerae uses to colonize aquatic amoebas. The study was published online on Aiugust 27, 2018 in Nature Communications. The open-access article is titled “Molecular Insights into Vibrio Cholerae's Intra-Amoebal Host-Pathogen Interactions.” The researchers demonstrated that the pathogen uses specific features that allow it to maintain its intra-amoebal replication niche and to ultimately escape from the succumbed host. Several of these features, including extracellular enzymes and motility, are considered minor virulence factors as they also play a role in human disease. The study suggests that the aquatic milieu provides a training ground for V. cholerae and that adaptation towards amoebal predators might have contributed to V. cholerae's emergence as a major human pathogen.
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