Gut Microbiota Can Inhibit Intestinal Serotonin Transporter through Activation of Toll-Like Receptor 2 (TLR2)

Researchers have found evidence that could shed new light on the complex community of trillions of microorganisms living in all our guts, and how they interact with our bodies. Scientists at the University of Exeter Medical School in the UK and the University of Zaragoza in Spain studied a protein known as Toll-like receptor 2 (TLR2) (image), a critical detector of the microbiota found in the intestine. TLR2 is a microbiota recognition receptor that has been described to contribute to intestinal homeostasis and to ameliorate inflammatory intestinal injury. In this new study, the scientists found that TLR2 regulates levels of serotonin - a neurotransmitter which carries messages to the brain, and is also found in the gut, where it regulates our bowel routines. The research, carried out in cell cultures and verified in mice, provides strong evidence that microbiota can interfere with human physiology by modulating the serotonin transporter activity. Serotonin transporter is a target for numerous diseases and it seems that microbiota living in our guts are able to interfere with this transporter by activation of TLR2, controlling our serotonin levels. The finding, published online on December 29, 2016 in PLOS ONE, comes as scientists across the world are working to understand the complicated interactions between the "invisible world" of the microbiota in our bodies and the impact they have on our health and even our moods. The open-access PLOS One article is titled “Intestinal Serotonin Transporter Inhibition by Toll-Like Receptor 2 Activation. A Feedback Modulation.” The finding may also help explain how the microbiota in our guts affect our physiology. Inflammatory bowel disease is thought to be triggered when TLR2 is not functioning properly, but so far, the mechanisms behind this have not been fully understood.
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