Groundbreaking Study Reveals Promising Therapeutic Approach for Prostate Cancer Bone Metastasis; MicroRNA Transferred Via Exosomes from Prostate Cancer Cells Plays Key Role in Development of Osteoblastic Lesions

Characterization of exosome section
In a study published in the July 2023 issue of Genes & Diseases, researchers from the Army Medical University and Shenzhen University in China have investigated the pivotal role of miR-18a-5p, a microRNA, in the development and progression of osteoblastic lesions resulting from prostate cancer (PCa) bone metastasis. The scientists made a striking observation of significantly elevated miR-18a-5p expression in the bone microenvironment of PCa patients with bone metastases, indicating its potential involvement in the pathogenesis of the disease. The open-access Genes & Medicine article is titled “Antagonizing Exosomal miR-18a-5p Derived from Prostate Cancer Cells Ameliorates Metastasis-Induced Osteoblastic Lesions by Targeting Hist1h2bc and Activating Wnt/β-Catenin Pathway.”
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