Glioblastoma Vaccine Shows Promising Results in Phase Ib Clinical Trial– More Than 20 Years in the Making, Autologous Tumor-Based Vaccine with Anti-Sense DNA Oligos Suspends Cancer Growth in Early-Stage Trial—Results Termed “Incredibly Important Advance”

Glioblastoma is the most aggressive type of primary brain cancer, one with a prognosis of 11-15 months with standard treatment. Results from a phase 1b clinical trial of a new experimental glioblastoma vaccine developed by Jefferson Health ( and Imvax (, both in Philadelphia, Pennsylvania, show the experimental treatment was tolerated well by patients, slowed tumor recurrence, and prolonged patient survival. The research was presented at an oral session (!/6812/presentation/9839)of the American Association for Cancer Research (AACR) 2019 annual meeting on March 31, 2019 in Atlanta, Georgia. The presentation was titled "Results of a Phase Ib Trial of an Autologous Cell Vaccine for Newly Diagnosed Glioblastoma." Researchers treated 33 patients with newly diagnosed glioblastoma multiforme (GBM) with the novel cancer vaccine (IGV-001) in a prospective phase 1b clinical study and compared outcomes to a historical comparator group of 35 patients treated with standard of care at the same institution. The results showed that patients treated with the vaccine had improved progression-free survival and overall survival compared to the control group treated with standard of care alone. "The response we see in some patients is very encouraging," says David Andrews (, MD, Professor of Neurosurgery at the Vickie & Jack Farber Institute for Neuroscience -- Jefferson Health ( and Co-Founder, Chief Medical Officer, and interim Chief Executive Officer of Imvax.
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