Gene-Edited Malaria Vaccine Warrants Further Study; Encouraging Immune-Response and Safety Data Emerge from Preliminary Human Test of Genetically Attenuated (Triple-Knockout) Malaria Parasite Vaccine

Findings from a preliminary human study of an experimental, genetically attenuated malaria parasite immunization show this vaccine warrants further exploration. The study’s proof-of-concept results were reported on August 24, 2022 in Science Translational Medicine. The research was headed by investigators at the University of Washington School of Medicine, Seattle Children’s Research Institute, and Kaiser Permanente Washington Health Research Institute. The article is titled “A Genetically Engineered Plasmodium falciparum Parasite Vaccine Provides Protection from Controlled Human Malaria Infection.”
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