The majority of gastric bypass patients mysteriously recover from their type 2 diabetes within days, before any weight loss has taken place. A study at Lund University Diabetes Centre in Sweden has now shown that the insulin-producing beta cells increase in number and performance after the surgery. "We have suspected this for a while, but there have not previously been any models to prove it," says Dr Nils Wierup, who led the research. The small study involved gastric bypass surgery on just four pigs, but is the only study of its kind and therefore unique. The results confirm that neither weight loss nor reduced food intake are required in order for the procedure to raise the number of beta cells, as the pigs had identical body weight and ate exactly the same amount of food. Type 2 diabetes develops when the body's insulin-producing beta cells stop working, or when the body is not able to use the insulin that the cells produce. The majority of people who suffer from obesity and undergo a gastric bypass operation recover from their diabetes within days of the procedure. The operation involves altering the connection between the stomach and the intestines so that food bypasses the stomach and parts of the small intestine and instead goes straight into the small intestine. Until now, it has been a mystery why patients' blood sugar levels normalize. The group at Lund University Diabetes Centre found that the pigs' beta cells improve their insulin secretion. The researchers also studied tissue from the pigs' pancreas, the organ where the beta cells are located, something that is almost impossible to do in humans. They found that the number of beta cells increased after the operation. The group have previously studied the effects of gastric bypass on humans.
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