Fred Hutch Scientists Will Cover Advances in Immunotherapy & Proteomics at AACR Annual Meeting

Scientists from the Fred Hutchinson Cancer Research Center in Seattle, Washington are scheduled to present and discuss the latest developments in immunotherapy and proteomics at the American Association for Cancer Research (AACR) Annual Meeting “Research Propelling Cancer Prevention and Cures” April 1-5 in Washington, D.C. What follows here is a selection of the more than 30 Hutch presentations scheduled to be given at the AACR gathering. Dr. Kristin Anderson, a postdoctoral fellow in Dr. Philip Greenberg's lab at Fred Hutch, will present findings on a new adoptive T-cell therapy for ovarian cancer, a type of solid tumor with a very low survival rate and few new treatment options. Dr. Anderson and her colleagues engineered T-cells to recognize a protein overproduced on these cancer cells, and then tested the therapy on human ovarian cancer cells in the lab and in a mouse model of ovarian cancer. The findings showed that the T-cells killed human ovarian cancer cells and that the treatment extended the mice's survival. But the research also highlighted how the tumor microenvironment of ovarian cancer presents unique challenges to the therapy. Dr. Anderson and her colleagues have identified several roadblocks to T-cell therapy that are unique to solid tumors (as compared with blood cancers, where T-cell therapy has progressed farther toward clinical benefit) and will present strategies underway in the Greenberg lab to overcome those roadblocks with new therapies. Dr. Anderson is speaking on April 4 at 3:50 p.m. Her talk is titled, "Engineering Adoptive T-Cell Therapy for Efficacy In Ovarian Cancer." From the Human Genome Project onward, we've made a massive investment in science aimed at understanding human genomics.
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