Sunday (October 29), the final day of the Annual Meeting of the American Association of Extracellular Vesicles featured two scientific sessions and ended at mid-day. Session 8 was the second meeting session on EVs in disease and was moderated by Vasily Yakovlev, MD, PhD, Virginia Commonwealth University School of Medicine The first talk was by Kate McAndrews, PhD, UT MD Anderson Cancer Center, who spoke on the early transfer of cancer-cell-derived CD9+ extracellular vesicles reprogramming the pancreatic tumor microenvironment. Next was Jennifer Jones, PhD, NIH, speaking on the role of standardization of ontology/measurement standards. She was followed by Dolores Di Vizio, MD, PhD, Cedars-Sinai Medical Center, who described the molecular and functional heterogeneity of cancer-derived extracellular vesicles. Next was Emanuele Cocucci, PhD, Ohio State University, who discussed extracellular vesicle exchange being favored by cell proximity. Christina Klasen, PhD, Particle Metrix then spoke on the next generation of NTA - fluorescence colocalization measurements. She was followed by Heather Pua, MD, PhD, Vanderbilt University speaking on how activated T cells secrete extracellular vesicles in the allergic airway and enhance eosinophil viability. The final talk of the session was given by Takahisa Nakamura, PhD, Cincinnati Children’s Hospital Medical Center, who spoke on the role of liver-derived extracellular vesicles and RNA cargos in the regulation of immunometabolism.