Endorsed by the International Society of Microbiota (ISM), and headed by Professor Jean Krutmann, IUF--Leibniz Research Institute for Environmental Medicine, Leibniz, Germany, the 13th International Conference on Skin Ageing & Challenges 2022will be held on 16-18 November16-18, 2022 at the Faculty of Pharmacy of the University of Lisbon, Portugal, and online. Skin Aging & Challenges 2022 will discuss the recent advances and therapeutical strategies in skin aging. A special session will be dedicated to Exosomes, Extracellular Vesicles, & Skin Aging. This session aims to point up and clarify the roles of extracellular vesicles in the aging microenvironment and age-related diseases. The therapeutic and anti-aging potential of extracellular vesicles derived from different sources, such as stem cells and commensal bacteria, will also be addressed.