Exosomes from Fat-Derived MSCs Can Deliver Potentially Therapeutic miRNA to Bladder Cancer Tumors in Mice

A new study published on April 20, 2022 in Cancer Medicine indicates that exosomes, or small vesicles, that transport molecules from one cell to another, can be effective vehicles for delivering cancer treatments to tumors. In the study, researchers used exosomes produced by cells called adipose-derived mesenchymal stem cells (ADSCs) to deliver an RNA-based anti-cancer treatment (miR-138-5p) to bladder cancer tumors in mice. “The present results reveal that ADSC-derived exosomes are an effective delivery vehicle for small molecule drugs in vivo, and exosome-delivered miR-138-5p is a promising therapeutic agent for bladder cancer treatment,” the authors wrote. The open-access article is titled “Evaluating Adipose-Derived Stem Cell Exosomes As miRNA Drug Delivery Systems for the Treatment of Bladder Cancer.” The work was led by researchers at the Medical University of Nanjing in China.
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