Exosomes Appear Involved in Progression of Breast Cancer, and Development of Treatment Resistance, in Breast Cancer Patients with Obesity, Type 2 Diabetes

Obesity, insulin resistance, and Type 2 diabetes are risk factors for breast cancer in post-menopausal women. The metabolic and inflammatory complications of obesity have a role in the formation of cancer. However, the cellular and molecular pathways that mediate breast cancer incidence, progression, and metastasis in patients who also have metabolic complications are still not fully understood. For the first time, researchers have found that exosomes (small vesicles secreted by all cell types studied and released into blood or nearby tissues and fluids), are involved in breast cancer progression and treatment resistance.

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