Exosome-Carried Alu RNA from Colorectal Cancer Cells Promotes CRC Progression

by Manisha Kashyap, PhD  

Representation of exosome and its cargo
In their study published March 14, 2024 in Experimental & Molecular Medicine, Sara Magliacane Trotta (Angiogenesis Lab, Institute of Genetics and Biophysics ‘Adriano Buzzati-Traverso’ Naples, Italy) et al. delve into the intricate mechanisms through which Alu RNA influences colorectal cancer (CRC) progression. The open-access article is titled “Cancer-Derived Exosomal Alu RNA Promotes Colorectal Cancer Progression.” Through meticulous experimentation and comprehensive analyses, the authors uncover a novel pathway wherein Alu RNA drives epithelial-mesenchymal transition (EMT) and fosters tumorigenesis in CRC cells. Their findings shed crucial light on the multifaceted impact of Alu RNA on CRC pathogenesis, unraveling a cascade of events that could reshape our understanding of cancer metastasis.
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