“Exhausted” Immune Cells (Microglia) May Drive Alzheimer’s

Microglial cell
Mice reach the twilight of their lives at around age two, the rough equivalent of 80 in human years. And when researchers introduce specific mutations into mice and then age them up, the mice can grow forgetful and irritable—eventually exhibiting signs of Alzheimer’s disease not unlike that of many elderly humans. Now, new research demonstrates that microglia, the immune cells of the brain, wither away as Alzheimer’s takes hold in both mice and humans, and that APOE4, a key gene variant implicated in Alzheimer’s, may mediate these changes. The new research was published in Immunity on January 9, 2024, in an open-access article titled “An Exhausted-Like Microglial Population Accumulates in Aged and APOE4 Genotype Alzheimer’s Brains.”
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