Exercise Improves Angiogenic Function of Circulating Exosomes in Type 2 Diabetes; Exosomal ATP7A and SOD3 Are Key to Exosome-Associated Increased Angiogenesis Via Delivery to Vessel-Lining Endothelial Cells

Image of Exosome Cross-Section and Contents
One way exercise can counter the damage of diabetes is by enabling activation of a natural system we have to grow new blood vessels when existing ones are ravaged by this disease, scientists report. Angiogenesis is the ability to form new blood vessels, and diabetes not only damages existing blood vessels, it hinders this innate ability to grow new ones in the face of disease and injury, say experts at the Vascular Biology Center at the Medical College of Georgia (MCG). Endothelial cells line our blood vessels and are essential to that new blood vessel growth. Now, the MCG scientists have the first evidence that in the face of diabetes, even one 45-minute session of moderate intensity exercise enables more exosomes, submicroscopic packages filled with biologically active cargo, to deliver directly to those cells more of the protein ATP7A, which can set angiogenesis in motion. They report this in an article published on February 10, 2022 in The FASEB Journal. The open-access article is titled “Exercise Improves Angiogenic Function of Circulating Exosomes in Type 2 Diabetes: Role of Exosomal SOD3.”
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