ERC Advanced Grant for Helle Ulrich for Research on DNA Repair and Genome Stability

European Research Council grants funding worth EUR 2.5 million

Professor Helle Ulrich

Professor Helle Ulrich, Executive Director of the Institute of Molecular Biology (IMB) and Professor at Johannes Gutenberg University Mainz (JGU), has been awarded an Advanced Grant from the European Research Council (ERC). She will receive EUR 2.5 million (~$2.68 million US dollars) over the next five years to support her research on how a small regulatory protein called ubiquitin contributes to DNA repair and the maintenance of genome stability. ERC Advanced Grants are among the most competitive and prestigious grants awarded to senior scientists in Europe. Ulrich's team specializes in understanding how cells repair DNA damage caused by genotoxic agents, such as UV radiation or mutagenic chemicals, and ensure that their DNA is accurately replicated when the cell divides. This is crucial for preventing mutations that can cause aging and cancer. The ERC Advanced Grant will allow her to investigate how a small, highly conserved regulatory protein called ubiquitin contributes to DNA replication and repair. Ubiquitin is a post-translational modifier attached to many proteins, including key proteins in DNA replication and repair pathways,and regulates their interactions, stability and activities in the cell.

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