Epigenetic Treatment in Mice Improves Spinal Cord Regeneration After Injury; Gene Activation Led to More Axon Growth, Regenerative Signaling, and Synaptic Plasticity

Dr. Simone Di Giovanni

Currently, spinal cord injury does not have any effective treatments; physical rehabilitation can help patients regain some mobility, but for severe cases, the outcomes are extremely limited by the failure of spinal neurons to regenerate naturally after injury. However, in a study publishing September 20, 2022 in the open-access journal PLoS Biology, researchers led by Simone Di Giovanni, PhD, at Imperial College London in the UK show that weekly treatments with an epigenetic activator can aid the regrowth of sensory and motor neurons in the spinal cord when given to mice 12 weeks after severe injury. The article is titled “CBP/p300 Activation Promotes Axon Growth, Sprouting, and Synaptic Plasticity In Chronic Experimental Spinal Cord Injury with Severe Disability.”

Login Or Register To Read Full Story