Epigenetic Changes to CRH Gene Linked to Severity of Suicide Attempts

Researchers have linked genetic changes in the corticotropin-releasing hormone (CRH) gene, which affects the regulation of the body's stress system, to suicide risk and psychiatric illness. The study of epigenetic changes in the body's hormone-based stress system has shown that stress-related changes in the CRH gene are linked to both serious suicide attempts in adults and psychiatric illness in adolescents. The research study, which is a collaboration among researchers at Umeå University, Karolinska Institutet, and Uppsala University in Sweden, was published online on December 18, 2017 in EBioMedicine. The open-access article is titled “Epigenetic Changes in the CRH Gene Are Related to Severity of Suicide Attempt and a General Psychiatric Risk Score in Adolescents.” Previous studies have indicated an overactive stress system in individuals with increased suicide risk. In the current study, researchers report that epigenetic changes in the CRH gene, which are linked to serious suicide attempts in adults, could also be found in adolescents with high risk of psychiatric illness. Recently published research output shows that serious suicide attempts lead to a heavily reduced lifespan with an increased suicide risk and risk of mortality from natural causes, particularly in adolescents. In the last ten years, it has become twice as common for Swedish adolescents between the ages of 10 and 17 to suffer from psychiatric illness. An alarming increase also in young adults can be seen. This is according to a recently published report from the Swedish National Board of Health and Welfare. In the current study described in EBioMedicine, researchers examined 88 individuals who had attempted suicide. The participants were divided into high- and low-risk groups based upon the severity of their suicidal behavior.
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