On March 30, 2023, it was announced that the American Association for Cancer Research (AACR) will award E. John Wherry, PhD, with the 2023 AACR-Cancer Research Institute (CRI) Lloyd J. Old Award in Cancer Immunology during the AACR Annual Meeting 2023, April 14-19 at the Orange County Convention Center in Orlando, Florida. Dr. Wherry is Chair of the Department of Systems Pharmacology and Translational Therapeutics, Director of the Institute for Immunology, and Founding Director of the Immune Health Project in the Perelman School of Medicine at the University of Pennsylvania. He is being honored for his major fundamental discoveries associated with deciphering the mechanisms of T-cell exhaustion in cancer, which has aided and informed research dedicated to establishing effective checkpoint blockade immunotherapies and has revealed novel approaches to reinvigorate T cells.